氏名

所属

連絡先

主な担当科目

主な研究テーマ

  1. シングルセル解析法の開発と臨床への応用研究(a)
  2. ゲノム・オミックス解析を基盤とした悪性腫瘍、炎症免疫組織の病態解明
  3. がん微小環境における細胞間相互作用の解明
  4. 肝炎ウイルスの発がんメカニズムの解明とその阻害剤に関する研究

研究分野

略歴

主な著書・論文

1 Hashimoto, S., Suzuki, T., Dong, H.-Y., Nagai, S., Yamazaki, N., and Matsushima, K. Serial analysis of gene expression in human monocyte-derived dendritic cells. PLENARY PAPER, Blood, 1999 94:845-852 2 Hashimoto, S., Komuro, I., Yamada, M., and Akagawa, K.S. IL-10 inhibits GM-CSF-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages. J Immunol., 2001 167:3619-3625 3 Hashimoto, S., Nagai, S., Sese, J., Suzuki, T., Obata, A., Sato, T., Toyoda, N., Dong, H.Y., Kurachi, M., Nagahata, T., Shizuno, K.I., Morishita, S., and Matsushima, K. Gene expression profile in human leukocytes. Blood, 2003 101:3509-3513 4 Hashimoto, S., Suzuki, Y., Kasai, Y., Morohoshi, k., Yamada, T., Sese, J., Morishita, S., Sugano, S., and Matsushima, K. 5’-end SAGE for the analysis of transcriptional start sites. Nat Biotechnol., 2004 22:1146-1149 5 Kasahara, M. et al., The medaka draft genome and insights into vertebrate genome evolution. Nature 447, 714-719. 2007 6 Rensing, S.A.et al., The Physcomitrella Genome Reveals Evolutionary Insights into the Conquest of Land by Plants. Science 319, 64-69. 2008 7 Hashimoto, S., Qu, W., Ahsan, B., Ogoshi, K., Sasaki, A., Nakatani, Y., Lee, Y., Ogawa, M., Ametani, A., Suzuki, Y., Sugano, S., Lee, C.C., Nutter, R.C., Morishita, S., and Matsushima, K. * High-resolution analysis of the 5'-end transcriptome using a next generation DNA sequencer. PLoS One, 2009 4:e4108 8 Sasaki, S., Mello, C.C., Shimada, A., Nakatani, Y., Hashimoto, S., Ogawa, M., Matsushima, K., Gu, S.G., Kasahara, M., Ahsan, B., Sasaki, A., Saito, T., Suzuki, Y., Sugano, S., Kohara, Y., Takeda, H., Fire, A., and Morishita, S. Chromatin-associated periodicity in genetic variation downstream of transcriptional start sites. Science , 2009 323:401-404 9 Hashimoto, S., K. Ogoshi, A. Sasaki, J. Abe, W. Qu, Y. Nakatani, B. Ahsan, K.Oshima, F. H. Shand, A. Ametani, Y. Suzuki, S. Kaneko, T. Wada, M. Hattori, S. Sugano, S. Morishita, and K. Matsushima. Coordinated changes in DNA methylation in antigen-specific memory CD4 T cells. J Immunol. , 2013 190:4076-4091 10 Hashimoto, S., Tabuchi, Y., Yurino, H., Hirohashi, Y., Deshimaru, S., Asano, T., Mariya, T., Oshima, K., Takamura, Y., Ukita, Y., Ametani, .A, Kondo N, Monma, N., Takeda, T., Misu, S., Okayama, T., Ikeo, K., Saito, T., Kaneko, S., Suzuki, Y., Hattori, M., Matsushima, K., Torigoe, T., Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues. Sci Rep. , 2017 doi:10.1038/s41598-017-14676-3

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